DNA is the fundamental building block for an individual's entire genetic map.  It is presented in the form of a double helix formed by base pairs attached to sugar-phosphate backbones which spiral around the outer surface of DNA

Between these backbones are 2 different sized grooves, designated the major and minor grooves.  These grooves are the site where regulatory proteins interact with DNA.  They recognise specific regions of DNA with a high selectivity and produce their activity by modulation of biochemistry of cells at the fundamental levels of DNA replication of key genes

A NEW CLASS

MGB's technology is represented by a new series of distinctive compounds having markedly different profiles from the only significant pharmaceutical product belonging to the class of DNA Minor Groove Binder.  The latter product is used in the treatment of cancer where a particular set of properties not shared with MGB Biopharma's compounds is essential for such efficacy in cancer.   The distinctive chemistry of our molecules carried out by original research by the University of Strathclyde results in selectivity such that bacteria, rather than mamallian cells are preferentially targeted 

antibacterial molecule bound to the minor groove of DNA

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