Our technology has allowed us to develop a new series of distinctive compounds with remarkably different profiles, all belonging to the class of DNA Minor Groove Binders (MGBs).

The distinctive chemistry of our most advanced series of molecules is based on work originally carried out by the University of Strathclyde in Glasgow.  The research team there were able to generate compounds which showed that bacterial cells are preferentially targeted.

DNA is the fundamental building block for an individual’s entire genetic map.  It is presented in the form of a double helix formed by base pairs attached to a sugar-phosphate backbone, which spirals around the outer surface of DNA.

Between these backbones are two different sized grooves, designated the major and minor grooves.  These grooves are the site where regulatory proteins interact with DNA.  They recognise specific regions of DNA with a high selectivity and produce their activity by cellular biochemistry modulation at the fundamental level of DNA replication of key genes.

Binding of MGB-BP-3 to the DNA minor groove; NMR-derived structure.
MGB 1 Picture1